HRD Evaluation in 4 types of Cancers

HRD (Homologous Recombination Deficiency) evaluation plays a crucial role in assessing the genetic characteristics and treatment strategies for various types of cancers. In breast cancer, it helps identify patients with DNA repair defects that may benefit from targeted therapies. In ovarian cancer...

• The discussion begins with a real-world patient scenario involving confusion over which genetic test to order for breast cancer, highlighting the evolution of BRCA testing to include HRR gene mutation panels and HRD tests. The lack of Indian companies offering HRD tests until recently, with Myriad Genetics' MyChoice CDx being the primary option, is emphasized. The importance of tumor-agnostic biomarkers and the shift away from organ-specific biomarkers like EGFR in lung cancer is discussed, noting that biomarkers are increasingly found across multiple cancer types due to shared oncogenesis mechanisms.