IVF Failures: How to Approach the Next Cycle

Repeated IVF failure can be challenging for both patients and clinicians, requiring a systematic reassessment before planning the next treatment cycle. This session will explore the evaluation of previous IVF outcomes, including ovarian response, embryo quality, endometrial receptivity, and...

• In vitro fertilization failure represents a multifactorial clinical challenge rather than a discrete single-disease entity, necessitating systematic evaluation across distinct biological checkpoints. According to international consensus from societies such as ESHRE and the American Society for Reproductive Medicine, an unsuccessful cycle requires clinicians to delineate the exact stage of failure, spanning gamete maturation, fertilization, embryogenesis, endometrial receptivity, transfer mechanics, and laboratory conditions. Embryo incompetence and aneuploidy represent the predominant etiology, driving over fifty percent of cycle failures, followed by impaired endometrial receptivity in twenty to twenty-five percent, gamete quality defects in fifteen to twenty percent, and technical or laboratory variations in ten to fifteen percent. Significant contributors include advanced reproductive age, diminished ovarian reserve, endometriosis, adenomyosis, metabolic dysfunction, and elevated sperm DNA fragmentation associated with severe oligoasthenoteratozoospermia.